Description
N-terminal His6-tagged recombinant, human PDGFRα amino acids 550 - end, containing the V561D mutation. This V561D mutation has been found in some patients with gastrointestinal stromal tumors and confers constitutive activity (Hirota S et al., Gastroenterology (2003); 125:660-667 and Lasota, J. et al., Laboratory Investigation (2004): 84: 874-883)